Genetic studies in NZB mice. V. Recombinant inbred lines demonstrate that separate genes control autoimmune phenotype.
نویسندگان
چکیده
منابع مشابه
Genetic studies in NZB mice. V. Recombinant inbred lines demonstrate that separate genes control autoimmune phenotype
The genetic basis for autoimmunity in NZB mice has been investigated through analysis of recombinant inbred lines produced by mating NZB mice with two different non-autoimmune strains. Several genes (at least six) were found to be necessary for the production of eight traits characteristic of the NZB mice that were studied. No fundamental genetic defect (an "autoimmunity gene") was identified t...
متن کاملRecombinant Inbred Lines and Genetic Reference Populations
The mouse is the most extensively used mammalian model for biomedical and aging research, and an extensive catalogue of laboratory resources is available to support research using mice: classical inbred lines, genetically modifi ed mice (knockouts, transgenics, and humanized mice), selectively bred lines, consomics, congenics, recombinant inbred panels, outbred and heterogeneous stocks, and an ...
متن کامل1188 Genetic Studies in Nzb Mice
The genetic basis for autoimmunity in New Zealand mice has been investigated for two decades. These studies have suggested that several genes underlie the autoimmune process (1-10). The advent of new murine models of autoimmunity that display some of the traits of NZB mice while lacking others has led to a resurgence of interest in the genetic basis for autoimmunity (11-14). The major question ...
متن کاملStudy of Genetic Diversity in Wheat Recombinant Inbred Lines by Factor Analysis
To identifying of the high yielding wheat lines with optimal characteristics and to determine the traits which could be used as the selection index for increasing of grain yield, 40 recombinant inbred lines derived from a cross between Norstar and Zagros cultivars were evaluated in a randomized complete block design with three replications. The measured characters consisted of peduncle weight, ...
متن کاملGenetic Diversity and Relationships of Agronomic Characters in Wheat Recombinant Inbred Lines
Objective: Wheat is the most important crop in Iran. Self sufficiency in wheat production is one of the economic and food safety policies in the country. In spite of the efforts which have been made in this area, the mean of wheat yield in Iran is less than its world average. Methods: In order to identifying of the high yielding wheat lines with optimal characteristics and to determine the trai...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1981
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.153.5.1187